Led by our understanding of T-cell biology, we’ve invented unique modular biotechnologies and programmable engineered human cells
Enabling us to systematically recreate how HLA-peptide targets are presented by cancer cells and how TCRs interact with those targets in a real cell biology context
By programming human cells in the lab we let biology show us the answers
eAPC
Engineered Antigen Presenting Cells
We have developed a novel system that uses engineered human cancer cells to recreate precisely how cancer-selective genes are processed to peptides and measure which HLA-peptide targets, or ‘antigens’, are presented by different patients.
eTPC
Engineered TCR Presenting Cells
We have generated standardised engineered T-cells to model how TCR drive recognition of HLA-peptide targets, enabling us to measure precisely and reproducibly the potency and specificity of TCRs against the diverse HLA-peptide targets.
TORES
TCR ORF Reconstitution and Engineering System
Our unique molecular genetics technology replicates in vitro the TCR gene assembly process within T-cells, allowing us to rapidly reconstitute and engineer TCR genes, or ‘Open Reading Frames’, in a precise and scalable manner.
CSTE
Cell Surface Tag Exchange
Our molecular identification and selection technology is built into all our engineered cells, enabling us to track precise gene transfer events. We do this by detecting the exchange of molecular tags on the cell surface, which is used to capture and manipulate living cells in the lab.