Precision at Scale

Anocca has developed a software ecosystem to model and capture the unique complexity of T-cell biology

Anocca OS is integral to how we work with biology at scale to harness T-cell immunity

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Store and Organise

Anocca OS has been specifically built to model the scope and complexity of T-cell biology. We operate our platform at scale, and accurately capture the relationships between the immense number of biological and data entities.  

Enabling powerful analysis and machine learning by amassing a wealth of highly annotated, quality controlled and quantitative datasets based on real biological outcomes.

Analyse and Visualise

Anocca OS enables us to navigate and interpret the immense amount of data our platform generates with custom data analysis pipelines and comprehensive visualisation tools. 

Our scientists can decipher T-cell biology with confidence, supporting our systematic approach to target mapping and product development.

Automate and Scale

Our platform is designed and built for automation and scale-up with Anocca OS at the core, enabling seamless automation and digitalisation. We’ve built tools for management of processes, reporting and organisation of resources.  We have begun building foundational AI models of T-cell biology to support and accelerate our platform outputs, including tools for personalisation of our therapeutics.

This enables us to efficiently build libraries of therapeutic products that can precisely address the massive target space for T-cells, with rigorous quality and traceability.

Visualisation and markup of biomolecules DNA, RNA and Protein is critical to T-cell biology. There are several very good open-source viewers around, but we wanted something light weight and modular, with a modern, sleek and intuitive interface. 

So, we built one. And open sourced it for anyone to use.

Featured here is a DNA molecule encoding two synthetic genes, with cancer targets. One contains fragments from a protein called KRAS with different mutations, and the other the whole protein for PRAME (yellow). Furthermore, we’ve annotated known HLA-peptide targets from both proteins, in the HLA alleles A*11:01 and A*02:01, respectively. Annotated are also several features critical for the “bioprogram” to run in cells hosting the DNA construct.

Use the mouse scroll to zoom in-out, pan left-right on the sequence. Select annotations or highlight sequences to get forward or reverse translations of the DNA into protein. Multi-select regions using Shift and Command buttons.

See if you can find the HLA-peptides in the sequence.

Our Software

Dysregulated Gene

Driver Mutation

Onco-viral

A*11:01 : G12V

A*11:01 : G12D

A*03:01 : G12V

Other HLAs : G12V

Other HLAs : G12D

Other Mutations

KRAS (Kirsten Rat Sarcoma Viral Oncogene Homolog), plays a crucial role in human cell signaling pathways. KRAS acts as a molecular switch in the MAPK/ERK pathway to regulate cell proliferation, differentiation, and survival. Mutations in KRAS can lead to uncontrolled cell growth, most of which are “Driver Mutations”, causing the development of multiple cancers.

Basic Info

KRAS

A*02 : R175H

The p53 protein plays a pivotal role in regulating cell cycle, DNA repair, and apoptosis to prevent genetic mutations and cancer development. As a transcription factor, it responds to DNA damage by either halting cell division to allow for repair or initiating programmed cell death if the damage is irreparable. Mutations in p53 are found in over half of all human cancers, underscoring its critical role in protecting cells from becoming cancerous.

A*02:01 : P29S

RAC1, a member of the Rho family of GTPases, is a crucial signaling molecule that regulates a wide array of cellular processes including actin cytoskeleton organization, cell growth, migration, and survival. Dysregulation of RAC1 activity is implicated in various pathological conditions, including cancer progression and metastasis.

RAC1

A*02:01

Other HLAs

PRAME (Preferentially Expressed Antigen in Melanoma) is a cancer-testis antigen that plays a role in the regulation of gene expression and immune response modulation. While its precise cellular functions are still being elucidated, PRAME is known to be involved in repressing retinoic acid signaling, a pathway crucial for cell differentiation and growth. This protein is typically expressed at low levels in normal tissues but is upregulated in various malignancies, including melanoma, leukemia, and several solid tumors.

PRAME

A*24

B*07

MAGE-A4 is a member of the MAGE (Melanoma Antigen Gene), involved in regulating key cellular mechanisms such as apoptosis and cell cycle control, although its exact function remains partially understood. Like its counterparts, MAGE-A4 is predominantly expressed in a wide range of cancers while being minimally present in normal tissues, making it an attractive candidate for cancer diagnostics and targeted therapies. Its involvement in cancer progression and potential role in immune system evasion underscore the therapeutic interest in targeting MAGE-A4 in oncology.

MAGE-A4

A*01:01

MAGE-A3 is a member of the MAGE (Melanoma Antigen Gene), characterized by its selective expression in cancer cells compared to normal tissues. It plays a role in the alteration of apoptotic pathways and immune recognition, contributing to tumor cell survival and proliferation. MAGE-A3 has been extensively studied as a target for cancer vaccines, especially in melanoma and non-small cell lung cancer, due to its immunogenic properties and prevalence in various tumor types.

MAGE-A3

MAGE-A1 is a member of the MAGE (Melanoma Antigen Gene) family, known for its role in immune evasion and cancer progression. This protein is typically silent in most normal adult tissues but becomes aberrantly expressed in a variety of cancers, including melanoma, breast, and lung cancers. MAGE-A1's function in tumorigenesis is still under investigation, but it is believed to modulate key cellular processes like apoptosis and cell cycle regulation. Its cancer-specific expression profile makes MAGE-A1 a promising target for cancer immunotherapy and vaccine development.

MAGE-A1

MAGE-A10 is a member of the MAGE (Melanoma Antigen Gene), known for its cancer-specific expression pattern, particularly in melanoma, lung, and bladder cancers. The protein is implicated in crucial cellular processes that contribute to tumor growth and metastasis. Although the precise mechanisms of MAGE-A10's action are not fully understood, its restricted expression in tumors versus normal tissues positions it as a valuable target for cancer immunotherapy approaches, including vaccines and adoptive T-cell therapies, aimed at eliciting a specific immune response against cancer cells expressing MAGE-A10.

MAGE-A10

NY-ESO-1, also known as Cancer/Testis Antigen 1B (CTAG1B), is a prominent member of the cancer-testis antigen family, characterized by its restricted expression to the testis in normal adult tissues and aberrant expression in a wide range of cancers, including melanoma, sarcoma, bladder, and esophageal cancers. The expression of NY-ESO-1 in tumors but not in most normal tissues makes it an attractive target for therapeutic cancer vaccines, T cell receptor-engineered T cell therapies, and other forms of immunotherapy.

NY-ESO-1

The E7 protein, produced by high-risk HPV strains, acts as a viral oncoprotein by binding to and inactivating the retinoblastoma protein (pRb), a critical tumor suppressor. This interaction releases E2F transcription factors, promoting cell cycle progression and unregulated cell division. E7's disruption of the pRb pathway allows infected cells to evade normal growth controls, contributing significantly to the oncogenic transformation process and the development of cancers associated with HPV infection.

Our Software

Precision at Scale

Anocca has developed a software ecosystem to model and capture the unique complexity of T-cell biology

Anocca OS is integral to how we work with biology at scale to harness T-cell immunity

Store and Organise

Analyse and Visualise

Automate and Scale

Purpose built to support every facet of our research and development

Our Interactive Sequence Viewer

Visualisation and markup of biomolecules DNA, RNA and Protein is critical to T-cell biology. There are several very good open-source viewers around, but we wanted something light weight and modular, with a modern, sleek and intuitive interface.

So, we built one. And open sourced it for anyone to use.

The molecule

Instructions

Use the mouse scroll to zoom in-out, pan left-right on the sequence. Select annotations or highlight sequences to get forward or reverse translations of the DNA into protein. Multi-select regions using Shift and Command buttons.

See if you can find the HLA-peptides in the sequence.

TCR-T Oncology

View our TCR-T oncology pipelines